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Testis‐specific protein, Y‐linked 1 activates PI 3K/ AKT and RAS signaling pathways through suppressing IGFBP 3 expression during tumor progression

28 Feb 2019

Abstract excerpt

The testis-specific protein, Y-linked 1 (TSPY1), a newly recognized cancer/testis antigen, has been suggested to accelerate tumor progression. However, the mechanisms underlying TSPY1 cancer-related function remain limited. By mining the RNA sequencing data of lung and liver tumors from The Cancer Genome Atlas, we found frequent ectopic expression of TSPY1 in lung adenocarcinoma (LUAD) and liver hepatocellular...

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PMID: 30815935
DOI: 10.1111/cas.13984

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