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Article

Adaptation and increased susceptibility to infection associated with constitutive expression of misfolded SP-C.

The Journal of cell biology - 30 Jan 2006

Bridges James P, Xu Yan, Na Cheng-Lun, Wong Hector R, Weaver Timothy E

Abstract excerpt

Mutations in the gene encoding SP-C (surfactant protein C; SFTPC) have been linked to interstitial lung disease (ILD) in children and adults. Expression of the index mutation, SP-C(Deltaexon4), in transiently transfected cells and type II cells of transgenic mice resulted in misfolding of the proprotein, activation of endoplasmic reticulum (ER) stress pathways, and cytotoxicity. In this study, we show that stably...

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Source

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Identifiers

PMID: 16449190
DOI: 10.1083/jcb.200508016
PMCID: PMC2063649

Genes

SFTPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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