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Article

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.

Cancer cell - 1 Aug 2005

Isaacs Jennifer S, Jung Yun Jin, Mole David R, Lee Sunmin, Torres-Cabala Carlos, Chung Yuen-Li, Merino Maria, Trepel Jane, Zbar Berton, Toro Jorge, Ratcliffe Peter J, Linehan W Marston, Neckers Len

Abstract excerpt

Individuals with hemizygous germline fumarate hydratase (FH) mutations are predisposed to renal cancer. These tumors predominantly exhibit functional inactivation of the remaining wild-type allele, implicating FH inactivation as a tumor-promoting event. Hypoxia-inducible factors are expressed in...

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Identifiers

PMID: 16098467
DOI: 10.1016/j.ccr.2005.06.017

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16098467-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.PMID 16098467Read ↗

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