Article
Nonsynonymous single-nucleotide polymorphisms of the human apoptosis-related endonuclease--DNA fragmentation factor beta polypeptide, endonuclease G, and Flap endonuclease-1--genes show a low degree of genetic heterogeneity.
DNA and cell biology - 1 Jan 2012
Takeshita Haruo, Fujihara Junko, Ueki Misuzu, Iida Reiko, Koda Yoshiro, Soejima Mikiko, Yuasa Isao, Kato Hideaki, Nakajima Tamiko, Kominato Yoshihiko, Yasuda Toshihiro
Abstract excerpt
DNA fragmentation factor beta (DFFB) polypeptide, endonuclease G (EndoG), and Flap endonuclease-1 (FEN-1) are responsible for DNA fragmentation, a hallmark of apoptosis. Although the human homologs of these genes show three, four, and six nonsynonymous single-nucleotide polymorphisms (SNPs), respectively, data on their genotype distributions in populations worldwide are limited. In this context, the objectives of...
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