Article
Apolipoprotein isoform E4 does not increase coronary heart disease risk in carriers of low-density lipoprotein receptor mutations.
Circulation. Cardiovascular genetics - 1 Dec 2011
Versmissen Jorie, Oosterveer Daniëlla M, Hoekstra Menno, Out Ruud, Berbée Jimmy F P, Blommesteijn-Touw Adriana C, van Vark-van der Zee Leonie, Vongpromek Ranitha, Vanmierlo Tim, Defesche Joep C, Mulder Monique, Kastelein John J P, Sijbrands Eric J G
Abstract excerpt
BACKGROUND: In humans, the E4 allele of the apolipoprotein E gene is associated with increased coronary heart disease risk. Surprisingly, in rodents, apolipoprotein E4 only accelerates the atherosclerotic process when transgenic for the human low-density lipoprotein receptor (LDLR) protein. We therefore investigated whether the LDLR locus interacted with the apolipoprotein E gene genotype on coronary heart...
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