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Article

NOTCH3 Pathogenic Variant and Risk of Age-Related Macular Degeneration: Findings From the Taiwan Biobank and Small Vessel Disease Registry.

Investigative ophthalmology & visual science - 2 Mar 2026

Chen Chih-Hao, Lin Chao-Wen, Wu Sing-Huei, Yang Zih-Wei, Lin Chien-Wei, Shen Ying-Chi, Cheng Yu-Wen, Su Ming-Wei, Tang Sung-Chun

Abstract excerpt

Purpose: Age-related macular degeneration (AMD) is a leading cause of central vision loss involving retinal microvascular dysfunction. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a hereditary small vessel disease caused by NOTCH3 mutations, primarily affects the cerebral vasculature but may also involve the retinal microvasculature. This study investigated...

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Source

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Identifiers

PMID: 41841652
DOI: 10.1167/iovs.67.3.37
PMCID: PMC13007416

Genes

NOTCH3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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NOTCH3 Pathogenic Variant and Risk of Age-Related Macular Degeneration: Findings From the Taiwan Biobank and Small Vessel Disease Registry.PMID 41841652Read ↗

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