Article
Size and conformation limits to secretion of disulfide-bonded loops in autotransporter proteins.
The Journal of biological chemistry - 9 Dec 2011
Leyton Denisse L, Sevastsyanovich Yanina R, Browning Douglas F, Rossiter Amanda E, Wells Timothy J, Fitzpatrick Rebecca E, Overduin Michael, Cunningham Adam F, Henderson Ian R
Abstract excerpt
Autotransporters are a superfamily of virulence factors typified by a channel-forming C terminus that facilitates translocation of the functional N-terminal passenger domain across the outer membrane of Gram-negative bacteria. This final step in the secretion of autotransporters requires a translocation-competent conformation for the passenger domain that differs markedly from the structure of the fully folded...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.