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Article

Detection of intergenerational genetic effects with application to HLA-B matching as a risk factor for schizophrenia.

Human heredity - 1 Jan 2011

Childs Erica J, Sobel Eric M, Palmer Christina G S, Sinsheimer Janet S

Abstract excerpt

BACKGROUND AND METHODS: Association studies using unrelated individuals cannot detect intergenerational genetic effects contributing to disease. To detect these effects, we improve the extended maternal-fetal genotype (EMFG) incompatibility test to estimate any combination of maternal effects, offspring effects, and their interactions at polymorphic loci or multiple SNPs, using any size pedigrees. We explore the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22004985
DOI: 10.1159/000332051
PMCID: PMC3721948

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