Article
Mapping of chromosome 1p deletions in myeloma identifies FAM46C at 1p12 and CDKN2C at 1p32.3 as being genes in regions associated with adverse survival.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2011
Boyd Kevin D, Ross Fiona M, Walker Brian A, Wardell Christopher P, Tapper William J, Chiecchio Laura, Dagrada Gianpaolo, Konn Zoe J, Gregory Walter M, Jackson Graham H, Child J Anthony, Davies Faith E, Morgan Gareth J
Abstract excerpt
PURPOSE: Regions on 1p with recurrent deletions in presenting myeloma patients were examined with the purpose of defining the deletions and assessing their survival impact. EXPERIMENTAL DESIGN: Gene mapping, gene expression, FISH, and mutation analyses were conducted on patient samples from the MRC Myeloma IX trial and correlated with clinical outcome data. RESULTS: 1p32.3 was deleted in 11% of cases, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.