Article
Gene expression profiling defines a high-risk entity of multiple myeloma.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences - 1 Apr 2007
Zhan Feng-Huang, Barlogie Bart, John D Shaughnessy
Abstract excerpt
Multiple myeloma (MM) is the second most common hematological malignancy and remains incurable. The marked variation in survival of patients with symptomatic myeloma ranging from few months to more than 15 years can be explained by differences in tumor mass, proliferative activity and, more recently, by cytogenetic and molecular genetic characteristics of the myeloma clone. Oligonucleotide microarray-based gene...
Topics
- Animals
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Humans
- Microarray Analysis
- Multiple Myeloma
- Plasma Cells
- Risk Factors