Article
Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.
Development (Cambridge, England) - 1 Nov 2011
Fukada So-ichiro, Yamaguchi Masahiko, Kokubo Hiroki, Ogawa Ryo, Uezumi Akiyoshi, Yoneda Tomohiro, Matev Miroslav M, Motohashi Norio, Ito Takahito, Zolkiewska Anna, Johnson Randy L, Saga Yumiko, Miyagoe-Suzuki Yuko, Tsujikawa Kazutake, Takeda Shin'ichi, Yamamoto Hiroshi
Abstract excerpt
Satellite cells, which are skeletal muscle stem cells, divide to provide new myonuclei to growing muscle fibers during postnatal development, and then are maintained in an undifferentiated quiescent state in adult skeletal muscle. This state is considered to be essential for the maintenance of satellite cells, but their molecular regulation is unknown. We show that Hesr1 (Hey1) and Hesr3 (Heyl) (which are known...
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