Article
[The effect of HSPB8 gene mutation on cell viability in Charcot-Marie-Tooth disease type 2L].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Oct 2011
Li Shu-jian, Tang Bei-sha, Zhao Guo-hua, Zhang Ru-xu, Xia Kun, Pan Qian
Abstract excerpt
OBJECTIVE: To study the effect of Charcot-Marie-Tooth 2L disease causing gene K141N mutation in heat shock protein B8 gene (HSPB8) on cell viability. METHODS: By using liposome transfection technique, (wt)HSPB8, (K141N)HSPB8 eukaryotic expression vector and green fluorescent protein (GFP) vector were transfected into SHSY-5Y cell, respectively. Twenty-four hours later, the cells were treated with 44 degree...
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