Article
What monozygotic twins discordant for phenotype illustrate about mechanisms influencing genetic forms of neurodegeneration.
Clinical genetics - 1 Apr 2012
Ketelaar M E, Hofstra E M W, Hayden M R
Abstract excerpt
As monozygotic (MZ) twins are believed to be genetically identical, discordance for disease phenotype between MZ twins has been used in genetic research to understand the contribution of genetic vs environmental factors in disease development. However, recent studies show that MZ twins can differ both genetically and epigenetically. Screening MZ twins for genetic and/or epigenetic differences could be a useful...
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