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Article

Modeling oncogene addiction using RNA interference.

Proceedings of the National Academy of Sciences of the United States of America - 26 Aug 2008

Rothenberg S Michael, Engelman Jeffrey A, Le Sheila, Riese David J, Haber Daniel A, Settleman Jeffrey

Abstract excerpt

The clinical efficacy of selective kinase inhibitors suggests that some cancer cells may become dependent on a single oncogene for survival. RNAi has been increasingly used to understand such "oncogene addiction" and validate new therapeutic targets. However, RNAi approaches suffer from significa...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18711136
DOI: 10.1073/pnas.0803217105
PMCID: PMC2517605

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18711136-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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