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Article

Reverse transcriptase genotypes in pediatric patients failing initial antiretroviral therapy in Gaborone, Botswana.

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) - 1 Jan 2000

Tolle Michael, Howard Leigh, Kirk Brianna, Gomila Andres, Schwarzwald Heidi, Anabwani Gabriel

Abstract excerpt

BACKGROUND: Limited data are available on patterns of resistance mutations in pediatric patients in southern Africa, where HIV-1 subtype C (HIV-1C) predominates. METHODS: Retrospective chart review of pediatric patients. Nucleoside reverse transcriptase inhibitor (NRTI)- and nonnucleoside reverse transcriptase inhibitor (NNRTI)-associated resistance mutations quantified from population-based sequencing genotypic...

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PMID: 21972264
DOI: 10.1177/1545109711422273

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