Article
Epidermal growth factor receptor pathway mutations and colorectal cancer therapy.
Archives of pathology & laboratory medicine - 1 Oct 2011
Grossmann Allie H, Samowitz Wade S
Abstract excerpt
CONTEXT: Rational anticancer therapy is beginning to expand the practice of surgical pathology beyond a primarily morphologic and immunophenotypic analysis into the molecular arena. Molecular testing of tumors can have both diagnostic and therapeutic value, which guides treatment decisions. This is true for colorectal cancer in which mutations in signaling mediators predict resistance to anti-epidermal growth...
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