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Article

EGFR Signaling in Colorectal Cancer: Novel Therapeutic Strategies, Predictive Biomarkers, and Counteracting Treatment Resistance.

International journal of molecular sciences - 3 Apr 2026

Abbas Noura, Mourad Mohamad, Smaily Hiba, Al Mahmasani Layal, Shamseddine Ali

Abstract excerpt

Colorectal cancer (CRC) remains a leading cause of cancer morbidity and mortality worldwide, with nearly one quarter of patients presenting with metastatic disease at diagnosis. The epidermal growth factor receptor (EGFR) plays a central role in CRC pathogenesis through activation of downstream RAS/RAF/MAPK and PI3K/AKT/mTOR signaling pathways, and has become a major therapeutic target. Anti-EGFR monoclonal...

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Topics

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Share to Antineoplastic Agents, Immunological
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Drug Resistance, Neoplasm

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Source

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Identifiers

PMID: 41977448
DOI: 10.3390/ijms27073265
PMCID: PMC13072906

Genes

EGFR
AREG
BRAF
EREG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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