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Article

Decreased p66Shc promoter methylation in patients with end-stage renal disease

1 Jan 2007

Abstract excerpt

BACKGROUND: p66Shc is a stress response protein and partially regulated by epigenetic modifications. Mice lacking p66Shc have reduced atherosclerosis, increased resistance to oxidative stress and a prolonged life time. The aim of the present study was to compare promoter methylation of the p66Shc gene between healthy controls and patients with end-stage renal disease (ESRD). There are two reasons for studying...

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Identifiers

PMID: 18067454
DOI: 10.1515/cclm.2007.357

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