Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Negative Cross Talk between NFAT1 and Stat5 Signaling in Breast Cancer

30 Sept 2011

Abstract excerpt

The molecular mechanisms that modulate the activity of the signal transducers and activators of transcription 5 (Stat5) during the progression of breast cancer remain elusive. Here, we present evidence that the calcineurin/nuclear factor of activated T cells (NFAT) pathway negatively regulates the activation of Stat5, and vice versa in breast cancer. NFAT1 interacts with Stat5 in breast cancer cells, and their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Cytokine Signaling Pathways and Interactions
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21964595
DOI: 10.1210/me.2011-1141

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Negative Cross Talk between NFAT1 and Stat5 Signaling in Breast CancerPMID 21964595Read ↗

NFAT Gene Family in Inflammation and CancerSemantic proximity Read ↗

In vivo identification of novel STAT5 target genesSemantic proximity Read ↗

Genomic Mutations of the STAT5 Transcription Factor Are Associated with Human Cancer and Immune Diseases.Semantic proximity Read ↗

Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancersSemantic proximity Read ↗

Reciprocal effects of STAT5 and STAT3 in breast cancer.Semantic proximity Read ↗

The tumor suppressor function of STAT1 in breast cancerSemantic proximity Read ↗

Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes MellitusSemantic proximity Read ↗

Loss of Stat5a delays mammary cancer progression in a mouse model.Semantic proximity Read ↗

Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.Semantic proximity Read ↗

Positive and negative regulation of EAAT2 by NF‐κB: a role for N‐myc in TNFα‐controlled repressionSemantic proximity Read ↗

Role of c-Myb during Prolactin-Induced Signal Transducer and Activator of Transcription 5a Signaling in Breast Cancer CellsSemantic proximity Read ↗

Expression of a carboxy terminally truncated Stat5 with no transactivation domain in the mammary glands of transgenic mice inhibits cell proliferation during pregnancy, delays onset of milk secretion, and induces apoptosis upon involution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.