Article
Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cells.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Sept 2001
Nicklin S A, Buening H, Dishart K L, de Alwis M, Girod A, Hacker U, Thrasher A J, Ali R R, Hallek M, Baker A H
Abstract excerpt
Gene therapy vectors based on adeno-associated virus-2 (AAV2) offer considerable promise for human gene therapy. Applications for AAV vectors are limited to tissues efficiently transduced by the vector due to its natural tropism, which is predominantly skeletal muscle, neurons, and hepatocytes. Tropism modification to elevate efficiency and/or selectivity to individual cell types would enhance the scope of AAV...
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