Article
A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo.
Hepatology (Baltimore, Md.) - 1 Feb 2012
Meuleman Philip, Catanese Maria Teresa, Verhoye Lieven, Desombere Isabelle, Farhoudi Ali, Jones Christopher T, Sheahan Timothy, Grzyb Katarzyna, Cortese Riccardo, Rice Charles M, Leroux-Roels Geert, Nicosia Alfredo
Abstract excerpt
UNLABELLED: Endstage liver disease caused by chronic hepatitis C virus (HCV) infection is the leading indication for liver transplantation in the Western world. However, immediate reinfection of the grafted donor liver by circulating virus is inevitable and liver disease progresses much faster than the original disease. Standard antiviral therapy is not well tolerated and usually ineffective in liver transplant...
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