Article
Homozygosity mapping on homozygosity haplotype analysis to detect recessive disease-causing genes from a small number of unrelated, outbred patients.
PloS one - 1 Jan 2011
Hagiwara Koichi, Morino Hiroyuki, Shiihara Jun, Tanaka Tomoaki, Miyazawa Hitoshi, Suzuki Tomoko, Kohda Masakazu, Okazaki Yasushi, Seyama Kuniaki, Kawakami Hideshi
Abstract excerpt
Genes involved in disease that are not common are often difficult to identify; a method that pinpoints them from a small number of unrelated patients will be of great help. In order to establish such a method that detects recessive genes identical-by-descent, we modified homozygosity mapping (HM) so that it is constructed on the basis of homozygosity haplotype (HM on HH) analysis. An analysis using 6 unrelated...
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