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Article

Pitfalls in homozygosity mapping.

American journal of human genetics - 1 Nov 2000

Miano M G, Jacobson S G, Carothers A, Hanson I, Teague P, Lovell J, Cideciyan A V, Haider N, Stone E M, Sheffield V C, Wright A F

Abstract excerpt

There is much interest in use of identity-by-descent (IBD) methods to map genes, both in Mendelian and in complex disorders. Homozygosity mapping provides a rapid means of mapping autosomal recessive genes in consanguineous families by identifying chromosomal regions that show homozygous IBD segments in pooled samples. In this report, we point out some potential pitfalls that arose during the course of...

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Identifiers

PMID: 11007652
DOI: 10.1016/S0002-9297(07)62966-8
PMCID: PMC1288578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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