Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Angiomyolipoma have common mutations in TSC2 but no other common genetic events.

PloS one - 1 Jan 2011

Qin Wei, Bajaj Vineeta, Malinowska Izabela, Lu Xin, MacConaill Laura, Wu Chin-Lee, Kwiatkowski David J

Abstract excerpt

Renal angiomyolipoma are part of the PEComa family of neoplasms, and occur both in association with Tuberous Sclerosis Complex (TSC) and independent of that disorder. Previous studies on the molecular genetic alterations that occur in angiomyolipoma are very limited. We evaluated 9 angiomyolipoma for which frozen tissue was available from a consecutive surgical series. Seven of 8 samples subjected to RT-PCR-cDNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Amplification
Share to Immunoenzyme Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Kidney Neoplasms

Share to Loss of Heterozygosity

Share to Monomeric GTP-Binding Proteins

Share to Neuropeptides

Share to Tuberous Sclerosis Complex 2 Protein

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21949787
DOI: 10.1371/journal.pone.0024919
PMCID: PMC3174984

Genes

TSC2
RHEB
TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Angiomyolipoma have common mutations in TSC2 but no other common genetic events.PMID 21949787Read ↗

Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development.Semantic proximity Read ↗

Constant allelic alteration on chromosome 16p (TSC2 gene) in perivascular epithelioid cell tumour (PEComa): genetic evidence for the relationship of PEComa with angiomyolipoma.Semantic proximity Read ↗

Loss of heterozygosity in the tuberous sclerosis (TSC2) region of chromosome band 16p13 occurs in sporadic as well as TSC-associated renal angiomyolipomas.Semantic proximity Read ↗

TSC2 inactivation, low mutation burden and high macrophage infiltration characterise hepatic angiomyolipomas.Semantic proximity Read ↗

Genotype-phenotype correlation of patients with tuberous sclerosis complex-associated renal angiomyolipoma: a descriptive study.Semantic proximity Read ↗

Germline mutation of TSC1 or TSC2 gene in Chinese patients with bilateral renal angiomyolipomas and mutation spectrum of Chinese TSC patients.Semantic proximity Read ↗

Genomic landscape and molecular evolutionary trajectories of renal epithelioid angiomyolipoma and benign angiomyolipoma.Semantic proximity Read ↗

New developments in the genetics and pathogenesis of tumours in tuberous sclerosis complex.Semantic proximity Read ↗

The Correlation Between Tuberous Sclerosis Complex Genotype and Renal Angiomyolipoma PhenotypeSemantic proximity Read ↗

Molecular Characterization of Malignant Renal Epithelioid Angiomyolipoma: A Review of Two Cases.Semantic proximity Read ↗

Angiomyolipoma/PEComa: the past, the present…and back to the future.Semantic proximity Read ↗

Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.