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Article

Toll-like receptor 7 and 8 polymorphisms: associations with functional effects and cellular and antibody responses to measles virus and vaccine.

Immunogenetics - 1 Mar 2012

Clifford Holly D, Yerkovich Stephanie T, Khoo Siew-Kim, Zhang Guicheng, Upham John, Le Souëf Peter N, Richmond Peter, Hayden Catherine M

Abstract excerpt

Successful defence against viral pathogens requires the rapid recognition of virus-specific "danger signals" and the activation of both innate and adaptive immunity. Toll-like receptors (TLR) 7 and 8 play a critical role in the elimination of viruses by recognising the common viral component, single stranded (ss)RNA. Measles virus, an ssRNA virus, continues to cause serious morbidity and mortality worldwide...

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Identifiers

PMID: 21947541
DOI: 10.1007/s00251-011-0574-0

Genes

TLR8
TLR7
TNF

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