Article
Aurora kinases are expressed in medullary thyroid carcinoma (MTC) and their inhibition suppresses in vitro growth and tumorigenicity of the MTC derived cell line TT.
BMC cancer - 26 Sept 2011
Baldini Enke, Arlot-Bonnemains Yannick, Sorrenti Salvatore, Mian Caterina, Pelizzo Maria R, De Antoni Enrico, Palermo Silvio, Morrone Stefania, Barollo Susi, Nesca Angela, Moretti Costanzo G, D'Armiento Massimino, Ulisse Salvatore
Abstract excerpt
BACKGROUND: The Aurora kinase family members, Aurora-A, -B and -C, are involved in the regulation of mitosis, and alterations in their expression are associated with cell malignant transformation. To date no information on the expression of these proteins in medullary thyroid carcinoma (MTC) are available. We here investigated the expression of the Aurora kinases in human MTC tissues and their potential use as...
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