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Article

Effects of the Aurora kinase inhibitor VX-680 on anaplastic thyroid cancer-derived cell lines

22 Apr 2008

Abstract excerpt

Anaplastic thyroid cancers (ATC) are aggressive tumors, which exhibit cell cycle misregulations leading to uncontrolled cellular proliferation and genomic instability. They fail to respond to chemotherapeutic agents and radiation therapy, and most patients die within a few months of diagnosis. In the present study, we evaluated the in vitro effects on ATC cells of VX-680, an inhibitor of the Aurora...

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PMID: 18430894
DOI: 10.1677/erc-08-0021

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