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Article

Cell cycle deregulation and TP53 and RAS mutations are major events in poorly differentiated and undifferentiated thyroid carcinomas.

The Journal of clinical endocrinology and metabolism - 1 Mar 2014

Pita Jaime Miguel, Figueiredo Inês Filipa, Moura Margarida Maria, Leite Valeriano, Cavaco Branca Maria

Abstract excerpt

BACKGROUND: Anaplastic thyroid carcinomas (ATCs) are among the most lethal malignancies, for which there is no effective treatment. OBJECTIVE: In the present study, we aimed to elucidate the molecular alterations contributing to ATC development and to identify novel therapeutic targets. DESIGN: We profiled the global gene expression of five ATCs and validated differentially expressed genes by quantitative RT-PCR...

Read the complete abstract on PubMed

Topics

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Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genes, p53

Share to Genes, ras

Share to Microarray Analysis

Share to Thyroid Carcinoma, Anaplastic

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 24423316
DOI: 10.1210/jc.2013-1512

Genes

AXIN1
BRAF
CTNNB1
PTEN
CDKN3
SNAI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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