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Article

A functional SNP upstream of the ADRB2 gene is associated with COPD.

International journal of chronic obstructive pulmonary disease - 1 Jan 2018

Li Jin-Xiu, Fu Wei-Ping, Zhang Jing, Zhang Xiao-Hua, Sun Chang, Dai Lu-Ming, Zhong Li, Yu Li, Zhang Ya-Ping

Abstract excerpt

Background: Previous studies have suggested that β2-adrenergic receptor (ADRB2) is associated with COPD. However, the role of genetic polymorphisms in ADRB2 on COPD has not been evaluated yet. Methods: In this study, SNaPshot genotyping, luciferase assay, chromatin immunoprecipitation and real-time polymerase chain reaction were adopted to investigate the association between ADRB2 genetic polymorphisms and COPD,...

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Identifiers

PMID: 29588580
DOI: 10.2147/COPD.S151153
PMCID: PMC5859892

Genes

ADRB2

Provenance

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