Article
Spontaneous allelic variant in deafness-blindness gene Ush1g resulting in an expanded phenotype.
Genes, brain, and behavior - 1 Aug 2023
Vartanian Vladimir, Krey Jocelyn F, Chatterjee Paroma, Curtis Allison, Six Makayla, Rice Sean P M, Jones Sherri M, Sampath Harini, Allen Charles N, Ryals Renee C, Lloyd R Stephen, Barr-Gillespie Peter G
Abstract excerpt
Relationships between novel phenotypic behaviors and specific genetic alterations are often discovered using target-specific, directed mutagenesis or phenotypic selection following chemical mutagenesis. An alternative approach is to exploit deficiencies in DNA repair pathways that maintain genetic integrity in response to spontaneously induced damage. Mice deficient in the DNA glycosylase NEIL1 show elevated...
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