Article
Association of genetic variations of the prostasin gene with essential hypertension in the Xinjiang Kazakh population.
Chinese medical journal - 1 Jul 2011
Li Nan-fang, Zhang Ju-hong, Chang Jian-hang, Yang Jin, Wang Hong-mei, Zhou Ling, Luo Wen-li
Abstract excerpt
BACKGROUND: Transgenic overexpression of human prostasin in rats disturbs salt balance and causes hypertension. We investigated whether genetic variations in prostasin were implicated in hypertension or related phenotypes in the Xinjiang Kazakh population. METHODS: We sequenced all exons and the promoter regions of the prostasin gene in 94 hypertensive individuals, and the genotype identification was performed by...
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