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Article

Membrane assembly of the triple-spanning coronavirus M protein. Individual transmembrane domains show preferred orientation.

The Journal of biological chemistry - 25 Oct 1992

Locker J K, Rose J K, Horzinek M C, Rottier P J

Abstract excerpt

The M protein of mouse hepatitis virus strain A59 is a triple-spanning membrane protein which assembles with an uncleaved internal signal sequence, adopting an NexoCcyt orientation. To study the insertion mechanism of this protein, domains potentially involved in topogenesis were deleted and the effects analyzed in topogenesis were deleted and the effects analyzed in several ways. Mutant proteins were synthesized...

Topics

Amino Acid Sequence
Animals
Cell Membrane
Cells, Cultured
Chlorocebus aethiops
Coronaviridae
Dogs
Fluorescent Antibody Technique
Glycosylation
HeLa Cells
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Protein Conformation

Viral Envelope Proteins

Viral Matrix Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1400501
PMCID: PMC8740634

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1400501-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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