Article
Clopidogrel metaboliser status based on point-of-care CYP2C19 genetic testing in patients with coronary artery disease.
Thrombosis and haemostasis - 5 May 2014
Erlinge David, James Stefan, Duvvuru Suman, Jakubowski Joseph A, Wagner Henrik, Varenhorst Christoph, Tantry Udaya S, Brown Patricia B, Small David, Moser Brian A, Sundseth Scott S, Walker Joseph R, Winters Kenneth J, Gurbel Paul A
Abstract excerpt
We compared results obtained with the Nanosphere Verigene® System, a novel point-of-care (POC) genetic test capable of analysing 11 CYP2C19 variants within 3 hours, to an established, validated genotyping method (Affymetrix™ DMET+; reference assay) for identifying extensive and reduced metabolisers of clopidogrel. Based on genotyping, patients (N=82) with stable coronary artery disease on clopidogrel 75 mg daily...
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