Article
Genetic polymorphisms in the serotonergic system and symptom clusters of major depressive disorder.
Journal of affective disorders - 1 Dec 2011
Kamata Mitsuhiro, Suzuki Akihito, Yoshida Keizo, Takahashi Hitoshi, Higuchi Hisashi, Otani Koichi
Abstract excerpt
BACKGROUND: It has been suggested that the symptoms of major depressive disorder (MDD) are composed of some clusters, which are linked to distinct genetic mechanisms. The purpose of this study was to examine the associations of genetic polymorphisms in the serotonergic system with three factors of the Montgomery-Åsberg Depression Rating Scale (MADRS), i.e., dysphoria, retardation, and vegetative symptoms....
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