Article
Mutant analysis approaches to understanding calcium signal transduction through calmodulin and calmodulin regulated enzymes.
Advances in experimental medicine and biology - 1 Jan 1990
Haiech J, Kilhoffer M C, Craig T A, Lukas T J, Wilson E, Guerra-Santos L, Watterson D M
Abstract excerpt
An example set of site-specific mutagenesis studies of calmodulin has been discussed in terms of strategy and how the results can provide insight into the functioning of calmodulin. A set of common examples for the study of calcium binding and enzyme activation were discussed. Essentially, site-specific mutagenesis in these initial studies is a perturbation approach. From these perturbation studies, structural...
Topics
- Amino Acid Sequence
- Animals
- Calcium
- Calmodulin
- Enzyme Activation
- Molecular Sequence Data
- Mutation
- Protein Engineering
- Signal Transduction