Article
Effects of hepatitis B virus precore and basal core promoter mutations on the expression of viral antigens: genotype B vs C.
Journal of viral hepatitis - 1 Oct 2011
Liu C-J, Cheng H-R, Chen C-L, Chen T-C, Tseng T-C, Wang Z-L, Chen P-J, Liu C-H, Chen D-S, Kao J-H
Abstract excerpt
Hepatitis B virus (HBV) genotypes/mutants are known to affect natural outcomes. The virologic differences among HBV genotype, precore and basal core promoter (BCP) mutations were investigated. HBV strains were isolated from 18 hepatitis B e antigen (HBeAg)-positive patients (nine genotype B and nine genotype C). All had precore and BCP wild-type sequences. After cloning of full-length HBV genome, the effects of...
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