Article

Temporal transcriptomic changes during neurodevelopment in a mouse model of Smith-Lemli-Opitz syndrome

2023-11-21

Abstract excerpt

Smith-Lemli-Opitz syndrome (SLOS) is a cholesterol biosynthesis disorder that arises from mutations in the gene DHCR7 , leading to decreased production of cholesterol and accumulation of its precursor, 7-dehydrocholesterol. SLOS displays a wide range of neurodevelopmental defects, intellectual disability, and behavioral problems. However, an in-depth study on the temporal changes of gene expression in the develop...

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Literature Corpus work: 745d8a15-9e91-5633-849e-f486972b3e1a
DOI: 10.1101/2023.11.21.568116

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