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Malformation syndromes caused by disorders of cholesterol synthesis

8 Oct 2010

Abstract excerpt

Cholesterol homeostasis is critical for normal growth and development. In addition to being a major membrane lipid, cholesterol has multiple biological functions. These roles include being a precursor molecule for the synthesis of steroid hormones, neuroactive steroids, oxysterols, and bile acids. Cholesterol is also essential for the proper maturation and signaling of hedgehog proteins, and thus cholesterol is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20929975
DOI: 10.1194/jlr.r009548

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