Article
Disruption of vascular homeostasis in patients with Kawasaki disease: involvement of vascular endothelial growth factor and angiopoietins.
Arthritis and rheumatism - 1 Jan 2012
Breunis Willemijn B, Davila Sonia, Shimizu Chisato, Oharaseki Toshiaki, Takahashi Kei, van Houdt Michel, Khor Chiea Chuen, Wright Victoria J, Levin Michael, Burns Jane C, Burgner David, Hibberd Martin L, Kuijpers Taco W
Abstract excerpt
OBJECTIVE: In Kawasaki disease (KD), a pediatric vasculitis of medium-sized arteries, the coronary arteries are most commonly affected. Angiopoietins and vascular endothelial growth factor (VEGF) play an important role in maintaining vascular homeostasis. Recently, we identified ANGPT1 and VEGFA as susceptibility loci for KD. This study was undertaken to fine-map these associations and to gain further insight...
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