Article
Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm.
Genomics - 1 Dec 2011
Hoffmann Thomas J, Zhan Yiping, Kvale Mark N, Hesselson Stephanie E, Gollub Jeremy, Iribarren Carlos, Lu Yontao, Mei Gangwu, Purdy Matthew M, Quesenberry Charles, Rowell Sarah, Shapero Michael H, Smethurst David, Somkin Carol P, Van den Eeden Stephen K, Walter Larry, Webster Teresa, Whitmer Rachel A, Finn Andrea, Schaefer Catherine, Kwok Pui-Yan, Risch Neil
Abstract excerpt
Four custom Axiom genotyping arrays were designed for a genome-wide association (GWA) study of 100,000 participants from the Kaiser Permanente Research Program on Genes, Environment and Health. The array optimized for individuals of European race/ethnicity was previously described. Here we detail the development of three additional microarrays optimized for individuals of East Asian, African American, and Latino...
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