Article
Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array.
Genomics - 1 Aug 2011
Hoffmann Thomas J, Kvale Mark N, Hesselson Stephanie E, Zhan Yiping, Aquino Christine, Cao Yang, Cawley Simon, Chung Elaine, Connell Sheryl, Eshragh Jasmin, Ewing Marcia, Gollub Jeremy, Henderson Mary, Hubbell Earl, Iribarren Carlos, Kaufman Jay, Lao Richard Z, Lu Yontao, Ludwig Dana, Mathauda Gurpreet K, McGuire William, Mei Gangwu, Miles Sunita, Purdy Matthew M, Quesenberry Charles, Ranatunga Dilrini, Rowell Sarah, Sadler Marianne, Shapero Michael H, Shen Ling, Shenoy Tanushree R, Smethurst David, Van den Eeden Stephen K, Walter Larry, Wan Eunice, Wearley Reid, Webster Teresa, Wen Christopher C, Weng Li, Whitmer Rachel A, Williams Alan, Wong Simon C, Zau Chia, Finn Andrea, Schaefer Catherine, Kwok Pui-Yan, Risch Neil
Abstract excerpt
The success of genome-wide association studies has paralleled the development of efficient genotyping technologies. We describe the development of a next-generation microarray based on the new highly-efficient Affymetrix Axiom genotyping technology that we are using to genotype individuals of European ancestry from the Kaiser Permanente Research Program on Genes, Environment and Health (RPGEH). The array contains...
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