Article
Mutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturation.
PLoS genetics - 1 Aug 2011
Eames B Frank, Yan Yi-Lin, Swartz Mary E, Levic Daniel S, Knapik Ela W, Postlethwait John H, Kimmel Charles B
Abstract excerpt
Differentiating cells interact with their extracellular environment over time. Chondrocytes embed themselves in a proteoglycan (PG)-rich matrix, then undergo a developmental transition, termed "maturation," when they express ihh to induce bone in the overlying tissue, the perichondrium. Here, we ask whether PGs regulate interactions between chondrocytes and perichondrium, using zebrafish mutants to reveal that...
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