Article
Mapping association between long-range cis-regulatory regions and their target genes using synteny.
Journal of computational biology : a journal of computational molecular cell biology - 1 Sept 2011
Mongin Emmanuel, Dewar Ken, Blanchette Mathieu
Abstract excerpt
In chordates, long-range cis-regulatory regions are involved in the control of transcription initiation (either as repressors or enhancers). Their main characteristics are that (i) they can be located as far as 1 Mb away from the transcription start site of the target gene, (ii) they can regulate more than one gene, and (iii) they are usually orientation-independent. Therefore, proper characterization of...
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