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Article

Association of vitamin D receptor gene start codon (Fok1) polymorphism with high myopia

1 Jan 2011

Abstract excerpt

BACKGROUND: High myopia caused primarily due to abnormal emmetropization and excessive axial ocular elongation is associated with sight-threatening ocular pathology. Muscular dysfunction of ocular ciliary muscles due to altered intracellular calcium levels can result in defective mechanotransduction of the eye and retinal defocus. The vitamin D3 receptor (VDR; a intracellular hormone receptor) is known to mediate...

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PMID: 21897619
DOI: 10.4103/0974-620x.83654

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