Article
Polymorphisms in genes that regulate cyclosporine metabolism affect cyclosporine blood levels and clinical outcomes in patients who receive allogeneic hematopoietic stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Jan 2012
Koh Youngil, Kim Inho, Shin Dong-Yeop, Bae Ji-Yeon, Kim Hyun-Kyung, Yoon Sung-Soo, Park Sung Sup, Lee Dong Soon, Park Seonyang, Kim Byung Kook
Abstract excerpt
In patients who received allogeneic hematopoietic stem cell transplantation (HSCT), we investigated the correlations between single nucleotide polymorphisms (SNPs) in genes that regulate cyclosporine metabolism and clinical outcomes. All patients received sibling-matched HSCT. DNA samples of patients and donors were analyzed for 4 SNPs: MDR1 +1236C>T (rs1128503), +2677G>T>A (rs2032582), +3435C>T (rs1045642), and...
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