Human G protein beta3 subunit variant does not alter hypercarbic or hypoxic ventilatory response.

doi:10.1046/j.1365-2281.2001.00366.x

Article

Human G protein beta3 subunit variant does not alter hypercarbic or hypoxic ventilatory response.

Clinical physiology (Oxford, England) - 1 Sept 2001

Exner H J, Groeben H, Rosskopf D, Siffert W, Peters J

Abstract excerpt

Hypercarbic respiratory drive is mainly determined by PCO(2) and pH with activity of the intracellular Na+/H+ exchanger (NHE) playing an important role in maintaining intracellular pH and respiratory drive. Because NHE activity varies with genetically different G-protein beta3 subunits (GNB3) (C/T polymorphism at nucleotide position 825) different genotypes might alter respiratory regulation. To test the...

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Human G protein beta3 subunit variant does not alter hypercarbic or hypoxic ventilatory response.

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