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Article

Allosteric communication in cysteinyl tRNA synthetase: a network of direct and indirect readout.

The Journal of biological chemistry - 28 Oct 2011

Ghosh Amit, Sakaguchi Reiko, Liu Cuiping, Vishveshwara Saraswathi, Hou Ya-Ming

Abstract excerpt

Protein structure networks are constructed for the identification of long-range signaling pathways in cysteinyl tRNA synthetase (CysRS). Molecular dynamics simulation trajectory of CysRS-ligand complexes were used to determine conformational ensembles in order to gain insight into the allosteric signaling paths. Communication paths between the anticodon binding region and the aminoacylation region have been...

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Share to Allosteric Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21890630
DOI: 10.1074/jbc.M111.246702
PMCID: PMC3199515

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