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Article

Removing allosteric feedback inhibition of tomato 4-coumarate:CoA ligase by directed evolution.

The Plant journal : for cell and molecular biology - 1 Jan 2012

Alberstein Moti, Eisenstein Miriam, Abeliovich Hagai

Abstract excerpt

Plant secondary metabolites, such as those derived from the phenylpropanoid pathway, have a beneficial effect on human health. Manipulation of metabolic flux in the phenylpropanoid pathway is important for achieving enhanced production of compounds such as anthocyanins, flavonoids and isoflavonoids. Here, we describe the development of a high-throughput molecular evolution approach that can be used for catalytic...

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PMID: 21883557
DOI: 10.1111/j.1365-313X.2011.04770.x

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