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Article

Fine-tuning tomato agronomic properties by computational genome redesign.

PLoS computational biology - 1 Jan 2012

Carrera Javier, Fernández Del Carmen Asun, Fernández-Muñoz Rafael, Rambla Jose Luis, Pons Clara, Jaramillo Alfonso, Elena Santiago F, Granell Antonio

Abstract excerpt

Considering cells as biofactories, we aimed to optimize its internal processes by using the same engineering principles that large industries are implementing nowadays: lean manufacturing. We have applied reverse engineering computational methods to transcriptomic, metabolomic and phenomic data obtained from a collection of tomato recombinant inbreed lines to formulate a kinetic and constraint-based model that...

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Identifiers

PMID: 22685389
DOI: 10.1371/journal.pcbi.1002528
PMCID: PMC3369923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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