Article
The use of historical data for identifying biologically unimportant but statistically significant results in genotoxicity assays.
Mutagenesis - 1 Mar 1990
Mitchell I D, Rees R W, Gilbert P J, Carlton J B
Abstract excerpt
The definition of a negative result is a problem in genetic toxicology. Here we suggest that a result may be considered biologically unimportant (negative) if it falls within the limits of variation usually found in the negative controls of the particular test. To determine 'usual' variation, we have set 95% confidence limits on three indices of variation, calculated from historical values for duplicate negative...
Topics
- Animals
- Confidence Intervals
- Genetic Variation
- Humans
- In Vitro Techniques
- Information Systems
- Mice
- Mutagenicity Tests
- Statistics as Topic